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SIM0500 has shown strong T cell cytotoxicity against MM cells by leveraging a combination of various antitumor effects.
January 13, 2025
By: Kristin Brooks
Managing Editor, Contract Pharma
AbbVie and Simcere Zaiming, a subsidiary of Simcere Pharmaceutical Group Ltd., entered an option to license agreement to develop SIM0500, an investigational new drug candidate in Phase 1 trials in relapsed or refractory multiple myeloma (MM), in both China and the U.S. SIM0500 is a humanized trispecific antibody that targets GPRC5D, BCMA, and CD3, developed independently by Simcere Zaiming using their T-cell engager polyspecific antibody technology platform. This molecule features a low affin...
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